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Breast Cancer. 2014 Jan;21(1):96-101. doi: 10.1007/s12282-012-0357-y. Epub 2012 Apr 17.

Prognostic significance of NANOG and KLF4 for breast cancer.

Author information

1
Department of Surgery and Science, Graduate School of Research Into Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama, Japan, g4440143@med.u-toyama.ac.jp.

Abstract

BACKGROUND:

Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.

METHODS:

In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.

RESULTS:

Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014).

CONCLUSIONS:

Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.

PMID:
22528804
DOI:
10.1007/s12282-012-0357-y
[Indexed for MEDLINE]

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