Format

Send to

Choose Destination
See comment in PubMed Commons below
Methods Mol Biol. 2012;874:177-92. doi: 10.1007/978-1-61779-800-9_14.

Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation.

Author information

1
Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA. ebieberich@georgiahealth.edu

Abstract

Recent studies show that bioactive lipids are important regulators for stem cell survival and differentiation. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically on embryonic stem (ES) cell differentiation. We show here simple methods to analyze sphingolipids in differentiating ES cells and to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.

PMID:
22528448
PMCID:
PMC3724173
DOI:
10.1007/978-1-61779-800-9_14
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center