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Methods Mol Biol. 2012;849:347-59. doi: 10.1007/978-1-61779-551-0_23.

Cell-to-cell transmission of α-synuclein aggregates.

Author information

1
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea.

Abstract

It is now recognized that the cell-to-cell transmission of misfolded proteins such as α-synuclein contributes to the neurodegenerative phenotype in neurological disorders such as idiopathic Parkinson's disease, Dementia with Lewy bodies, and Parkinson's disease dementia. Thus, establishing cell-based models for the transmission of α-synuclein is of importance to understand the mechanisms of neurodegeneration in these disorders and to develop new therapies. Here we describe methods to study the neuron-to-neuron propagation of α-synuclein in an in vitro setting that also has in vivo applications.

PMID:
22528101
PMCID:
PMC4940116
DOI:
10.1007/978-1-61779-551-0_23
[Indexed for MEDLINE]
Free PMC Article

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