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Diabetologia. 2012 Aug;55(8):2132-41. doi: 10.1007/s00125-012-2550-0. Epub 2012 Apr 12.

Dietary saturated fat and fibre and risk of cardiovascular disease and all-cause mortality among type 1 diabetic patients: the EURODIAB Prospective Complications Study.

Collaborators (131)

Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu-Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, Fossarello M, Ferriss J, Grealy G, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto V, Idzior-Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes-Stuffken J, Nunes-Correa J, Rogado M, Gardete-Correia L, Cardoso M, Silva A, Boavida J, Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Soussan D, Verier-Mine O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Perin P, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Ward J, Roglic G, Metelko Z, Pepeonik Z, Fuller J, Karamanos B, Chaturvedi N, Toeller M, Pozza G, Ferriss B, Porta M, Rottiers R, Michel G, Fuller J, Chaturvedi N, Holloway J, Webb D, Asbury L, Viberti G-, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Toeller M, Scherbaum WA, Gries FA.

Author information

Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands.



Low adherence to recommendations for dietary saturated fatty acid (SFA) and fibre intake in patients with type 1 diabetes mellitus may heighten their increased risk of cardiovascular disease (CVD) and mortality. We examined the relationship of SFA and total, soluble and insoluble fibre with incident CVD and all-cause mortality in type 1 diabetic patients.


A prospective cohort analysis was performed in 2,108 European type 1 diabetic patients aged 15-60 years who were free of CVD at baseline and enrolled in the EURODIAB Prospective Complications Study (51% male). Diet was assessed from a standardised 3 day dietary record. HR were calculated using Cox proportional hazards models.


During a mean follow-up of 7.3 years, 148 incident cases of fatal and non-fatal CVD and 46 all-cause deaths were documented. No statistically significant association was found between SFA and CVD and all-cause mortality. Total dietary fibre, per 5 g/day, was associated with lower all-cause mortality risk (HR 0.72; 95% CI 0.55, 0.95). This association was stronger for soluble fibre (per 5 g/day, HR 0.34; 95% CI 0.14, 0.80) compared with insoluble fibre (per 5 g/day; HR 0.66; 95% CI 0.45, 0.97). Similar results were found for the association with CVD.


This study suggests that reported dietary SFA is not significantly associated with CVD and all-cause mortality in type 1 diabetic patients. On the contrary, higher dietary fibre consumption, especially soluble fibre, within the range commonly consumed by type 1 diabetic patients, may contribute to the prevention of CVD and all-cause mortality in type 1 diabetic patients.

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