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J Sports Med Phys Fitness. 2012 Apr;52(2):165-9.

Creatine ingestion effects on oxidative stress in a steady-state test at 75% VO(2max).

Author information

  • 1Department of Bio-Medical Sciences, University of Catania, Catania, Italy. marinella.coco@unict.it

Abstract

AIM:

The present study was carried out with the aim to analyze the role of creatine on oxidative stress during exercise, i.e. whether creatine is a pro-oxidative or an antioxidant substance.

METHODS:

In a randomized double-blind study involving 30 adult males, we examined plasma lactate, oxidative stress markers (malondialdehyde, MDA) and glutathione redox ratio (GSSG·GSH-1), antioxidative systems (vitamins A, E, C), and ergospirometric responses (respiratory quotient and relative oxygen uptake) before and after 30 min steady-state tests 75% VO2max (placebo and creatine).

RESULTS:

Ergospirometric tests, hematocrit values, blood lactate as well as vitamins A, E and C concentrations did not show significant differences between creatine and placebo testing. Conversely, oxidative stress markers MDA and GSSG·GSH-1 increased during placebo trials much more than in creatine trials.

CONCLUSION:

This is the first report documenting that a creatine loading, i.e., a 0.3 g/kg/die of creatine ingestion for 5 consecutive days, could reduce the oxidative stress, whereas its consumption may not have a clear metabolic advantage in certain aerobic activities.

PMID:
22525652
[PubMed - indexed for MEDLINE]
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