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Paediatr Int Child Health. 2012 Feb;32(1):47-50. doi: 10.1179/1465328111Y.0000000042.

Myasthenia gravis in Jamaican children: a 12-year institutional review.

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1
University of the West Indies, Kingston 7, St Andrew, Jamaica. roxanne.melbournechambers@uwimona.edu.jm

Abstract

BACKGROUND:

Myasthenia gravis is uncommon in children. The clinical characteristics in children of the English-speaking Caribbean have not been documented previously.

OBJECTIVE:

To describe the clinical characteristics and outcome of children with myasthenia gravis at two tertiary hospitals in Jamaica.

METHODS:

The case-notes of all children with a diagnosis of myasthenia gravis managed at the University Hospital of the West Indies and Bustamante Hospital for Children between January 1994 and December 2005 were reviewed.

RESULTS:

There were 34 children; mean age of onset of illness was 7.5 years and mean period of follow-up was 38.5 months. The male-to-female ratio was 1:1.3. Nineteen (59%) presented with ocular manifestations; 47% of these developed signs of generalised involvement. Most were treated with pyridostigmine and prednisone. Eight patients had thymectomy. Four patients (12%) entered remission. There were two deaths.

CONCLUSIONS:

Myasthenia gravis in Jamaican children is similar to that in other populations. It is more common in female children. Most children present with ocular manifestations and remission occurs infrequently.

PMID:
22525448
DOI:
10.1179/1465328111Y.0000000042
[Indexed for MEDLINE]
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