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Cell Res. 2012 Aug;22(8):1207-9. doi: 10.1038/cr.2012.68. Epub 2012 Apr 24.

Leucyl-tRNA synthetase: double duty in amino acid sensing.

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1
Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

Erratum in

  • Cell Res. 2012 Oct;22(10):1509.

Abstract

The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.

PMID:
22525334
PMCID:
PMC3411172
DOI:
10.1038/cr.2012.68
[Indexed for MEDLINE]
Free PMC Article

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