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Cell Res. 2012 May;22(5):793-805. doi: 10.1038/cr.2012.64. Epub 2012 Apr 24.

Polarized sorting and trafficking in epithelial cells.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

Abstract

The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.

PMID:
22525333
PMCID:
PMC3343658
DOI:
10.1038/cr.2012.64
[Indexed for MEDLINE]
Free PMC Article

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