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Bioorg Med Chem Lett. 2012 May 15;22(10):3550-3. doi: 10.1016/j.bmcl.2012.03.096. Epub 2012 Apr 6.

Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens.

Author information

1
Laboratories for Chemical Biology Umeå, Department of Chemistry, Umeå University, Umeå, Sweden.

Abstract

Small molecule screening identified 5-nitro-7-((4-phenylpiperazine-1-yl-)methyl)quinolin-8-ol INP1750 as a putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. In this study we report structure-activity relationships for inhibition of T3S and show that the most potent compounds target both the extracellular bacterium Y. pseudotuberculosis and the intracellular pathogen Chlamydia trachomatis in cell-based infection models.

PMID:
22525317
DOI:
10.1016/j.bmcl.2012.03.096
[Indexed for MEDLINE]

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