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J Reprod Med. 2012 Mar-Apr;57(3-4):148-52.

Intercellular adhesion molecule-1 K469E polymorphism: Is it associated with preeclampsia in the Korean population?

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Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Graduate School of Medicine, Yonsei University, and Yonsei University Health System, Seoul, Republic of Korea.



To examine whether the distribution of genotypic and allelic frequencies of ICAM-1 K469 of Korean women with preeclampsia are different from that of a control group.


In this case-control study the ICAM-1 K469E polymorphism was genotyped in 42 women with preeclampsia and 138 normotensive controls who had delivered at least two normal, term infants. A direct sequencing reaction method was used to detect a single nucleotide polymorphism.


The distribution of genotype frequencies and the frequency of the K469 allele of the preeclampsia group were not significantly different from those of the controls. A similar trend was observed between the severe preeclampsia patients and the controls.


The frequencies of the KK genotype and the K allele were higher in the preeclampsia group than those in the control group. However, there was no statistically significant difference.

[Indexed for MEDLINE]

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