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J Infect. 2012 Aug;65(2):165-72. doi: 10.1016/j.jinf.2012.04.005. Epub 2012 Apr 17.

Long-term chikungunya infection clinical manifestations after an outbreak in Italy: a prognostic cohort study.

Author information

1
Area Rischio Infettivo, Agenzia Sanitaria e Sociale Regione Emilia-Romagna, Viale Aldo Moro 21, Bologna, Italy. mlmoro@regione.emilia-romagna.it

Abstract

OBJECTIVES:

Following a Chikungunya (CHIKV) outbreak in Italy, a cohort study was conducted to describe the infection long-term clinical course and outcome.

METHODS:

Persons identified through active and passive surveillance as confirmed or possible CHIKV cases during the outbreak were enrolled and interviewed by trained public health nurses, between 4-5 and 12-13 months following the acute stage. Patients reporting persistent clinical symptoms were evaluated by rheumatologists. Serum samples were obtained and anti-CHIKV specific IgG and IgM immune responses detected. Only confirmed cases who completed the follow-up were analysed.

RESULTS:

Out of 250 patients, 66.5% still reported myalgia, asthenia or arthralgia (most frequent sign) after 12 months. Functional ability, measured by the ROAD index, was more impaired for lower extremities (3.75; Inter Quartile Range - IQR 4.4), and the activities of daily living (average 4.2; IQR 5). Variables independently associated with the presence of joint pain at 12-13 months were increasing age, and history of rheumatologic diseases). Elderly, females, and persons with history of rheumatologic diseases had higher anti-CHIKV IgG titres at 12-13 months.

CONCLUSIONS:

This study confirms, in an unselected population, that the long-lasting burden of CHIKV infection is significant.

PMID:
22522292
DOI:
10.1016/j.jinf.2012.04.005
[Indexed for MEDLINE]

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