Format

Send to

Choose Destination
See comment in PubMed Commons below
DNA Cell Biol. 2012 Oct;31 Suppl 1:S49-61. doi: 10.1089/dna.2012.1654. Epub 2012 Apr 20.

Epigenetic mechanisms in commonly occurring cancers.

Author information

1
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA. lauren.blair@yale.edu

Abstract

Cancer is a collection of very complex diseases that share many traits while differing in many ways as well. This makes a universal cure difficult to attain, and it highlights the importance of understanding each type of cancer at a molecular level. Although many strides have been made in identifying the genetic causes for some cancers, we now understand that simple changes in the primary DNA sequence cannot explain the many steps that are necessary to turn a normal cell into a rouge cancer cell. In recent years, some research has shifted to focusing on detailing epigenetic contributions to the development and progression of cancer. These changes occur apart from primary genomic sequences and include DNA methylation, histone modifications, and miRNA expression. Since these epigenetic modifications are reversible, drugs targeting epigenetic changes are becoming more common in clinical settings. Daily discoveries elucidating these complex epigenetic processes are leading to advances in the field of cancer research. These advances, however, come at a rapid and often overwhelming pace. This review specifically summarizes the main epigenetic mechanisms currently documented in solid tumors common in the United States and Europe.

PMID:
22519822
PMCID:
PMC3460614
DOI:
10.1089/dna.2012.1654
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc. Icon for PubMed Central
    Loading ...
    Support Center