Format

Send to

Choose Destination
Br J Pharmacol. 2012 Sep;167(2):256-78. doi: 10.1111/j.1476-5381.2012.01975.x.

The solute carrier 6 family of transporters.

Author information

1
Research School of Biology, Australian National University, Canberra, ACT, Australia. Stefan.broer@anu.edu.au

Abstract

The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

PMID:
22519513
PMCID:
PMC3481037
DOI:
10.1111/j.1476-5381.2012.01975.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center