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Chem Sci. 2012 Jan 1;2012(3):633-658. Epub 2012 Jan 25.

Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development.

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Merck Center for Catalysis at Princeton University, Princeton, New Jersey, 08544, USA; ; Tel: +1 609 2582254.


Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

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