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Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.

Cubedo E, Gentles AJ, Huang C, Natkunam Y, Bhatt S, Lu X, Jiang X, Romero-Camarero I, Freud A, Zhao S, Bacchi CE, Martínez-Climent JA, Sánchez-García I, Melnick A, Lossos IS.

Blood. 2012 Jun 7;119(23):5478-91. doi: 10.1182/blood-2012-01-403154. Epub 2012 Apr 19.


KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.

Kim JY, Kim KB, Eom GH, Choe N, Kee HJ, Son HJ, Oh ST, Kim DW, Pak JH, Baek HJ, Kook H, Hahn Y, Kook H, Chakravarti D, Seo SB.

Mol Cell Biol. 2012 Jul;32(14):2917-33. doi: 10.1128/MCB.00133-12. Epub 2012 May 21.


LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M.

Science. 2003 Oct 17;302(5644):415-9. Erratum in: Science. 2003 Oct 24;302(5645):568.


Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.

Koyano-Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen TL, Borges L, Zirbes KM, Li T, Perlingeiro RC, Kyba M, Garry DJ.

Stem Cells. 2012 Aug;30(8):1611-23. doi: 10.1002/stem.1131.


Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA.

Blood. 2011 Aug 11;118(6):1579-90. doi: 10.1182/blood-2010-08-300343. Epub 2011 Jun 13.


Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells.

Deleuze V, El-Hajj R, Chalhoub E, Dohet C, Pinet V, Couttet P, Mathieu D.

PLoS One. 2012;7(7):e40484. doi: 10.1371/journal.pone.0040484. Epub 2012 Jul 6.


The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.

McCormack MP, Young LF, Vasudevan S, de Graaf CA, Codrington R, Rabbitts TH, Jane SM, Curtis DJ.

Science. 2010 Feb 12;327(5967):879-83. doi: 10.1126/science.1182378. Epub 2010 Jan 21.


Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.

Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP.

Blood. 2011 May 19;117(20):5453-62. doi: 10.1182/blood-2010-09-309831. Epub 2011 Mar 22.


miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β.

Sun W, Shen W, Yang S, Hu F, Li H, Zhu TH.

Cell Res. 2010 Oct;20(10):1158-69. doi: 10.1038/cr.2010.134. Epub 2010 Sep 21.


Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.

Cleveland SM, Smith S, Tripathi R, Mathias EM, Goodings C, Elliott N, Peng D, El-Rifai W, Yi D, Chen X, Li L, Mullighan C, Downing JR, Love P, Davé UP.

Stem Cells. 2013 May;31(5):882-94. doi: 10.1002/stem.1345.


Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.

El Omari K, Hoosdally SJ, Tuladhar K, Karia D, Vyas P, Patient R, Porcher C, Mancini EJ.

Blood. 2011 Feb 17;117(7):2146-56. doi: 10.1182/blood-2010-07-293357. Epub 2010 Nov 12.


Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos.

Weiss O, Kaufman R, Michaeli N, Inbal A.

Dev Biol. 2012 Sep 15;369(2):191-8. doi: 10.1016/j.ydbio.2012.06.029. Epub 2012 Jul 20.


A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.

Zhou S, Mody D, DeRavin SS, Hauer J, Lu T, Ma Z, Hacein-Bey Abina S, Gray JT, Greene MR, Cavazzana-Calvo M, Malech HL, Sorrentino BP.

Blood. 2010 Aug 12;116(6):900-8. doi: 10.1182/blood-2009-10-250209. Epub 2010 May 10.


Upstream distal regulatory elements contact the Lmo2 promoter in mouse erythroid cells.

Bhattacharya A, Chen CY, Ho S, Mitchell JA.

PLoS One. 2012;7(12):e52880. doi: 10.1371/journal.pone.0052880. Epub 2012 Dec 21.


Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody.

Agostinelli C, Paterson JC, Gupta R, Righi S, Sandri F, Piccaluga PP, Bacci F, Sabattini E, Pileri SA, Marafioti T.

Histopathology. 2012 Jul;61(1):33-46. doi: 10.1111/j.1365-2559.2012.04198.x. Epub 2012 Mar 6.


Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components.

Younes SF, Beck AH, Lossos IS, Levy R, Warnke RA, Natkunam Y.

Am J Surg Pathol. 2010 Sep;34(9):1266-76. doi: 10.1097/PAS.0b013e3181e9343d.


The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia.

Curtis DJ, McCormack MP.

Clin Cancer Res. 2010 Dec 1;16(23):5618-23. doi: 10.1158/1078-0432.CCR-10-0440. Epub 2010 Sep 22. Review.


PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL.

Cubedo E, Maurin M, Jiang X, Lossos IS, Wright KL.

FEBS J. 2011 Sep;278(17):3065-75. doi: 10.1111/j.1742-4658.2011.08227.x. Epub 2011 Aug 2.


LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome.

Malumbres R, Fresquet V, Roman-Gomez J, Bobadilla M, Robles EF, Altobelli GG, Calasanz MJ, Smeland EB, Aznar MA, Agirre X, Martin-Palanco V, Prosper F, Lossos IS, Martinez-Climent JA.

Haematologica. 2011 Jul;96(7):980-6. doi: 10.3324/haematol.2011.040568. Epub 2011 Apr 1.


Usefulness of HGAL and LMO2 immunohistochemistry in the identification of follicular lymphomas of the non-gastric gastrointestinal tract.

Chapman-Fredricks J, Younes SF, Fan YS, Sandoval-Sus JD, Natkunam Y, Lossos IS.

Appl Immunohistochem Mol Morphol. 2013 May;21(3):200-4. doi: 10.1097/PAI.0b013e31826399aa.


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