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Plant Signal Behav. 2012 May;7(5):581-8. doi: 10.4161/psb.19694. Epub 2012 Apr 20.

Catalytic mechanism and kinase interactions of ABA-signaling PP2C phosphatases.

Author information

1
Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, MI, USA.

Abstract

Abscisic acid (ABA) is an essential hormone that controls plant growth, development and responses to abiotic stresses. ABA signaling is mediated by type 2C protein phosphatases (PP2Cs), including HAB1 and ABI2, which inhibit stress-activated SnRK2 kinases and whose activity is regulated by ABA and ABA receptors. Based on biochemical data and our previously determined crystal structures of ABI2 and the SnRK2.6-HAB1 complex, we present the catalytic mechanism of PP2C and provide new insight into PP2C-SnRK2 interactions and possible roles of other SnRK2 kinases in ABA signaling.

PMID:
22516825
PMCID:
PMC3419024
DOI:
10.4161/psb.19694
[Indexed for MEDLINE]
Free PMC Article

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