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Emerg Infect Dis. 2012 May;18(5):767-74. doi: 10.3201/eid1805.110812.

Temporal trends in Bordetella pertussis populations, Denmark, 1949-2010.

Author information

1
Statens Serum Institut, Copenhagen, Denmark. rfp@ssi.dk

Abstract

We used multilocus variable-number tandem repeat analysis and multiple antigen sequence typing to characterize isolates of Bordetella pertussis strains circulating in Denmark during periods with and without pertussis vaccination coverage. Our results show substantial shifts in the B. pertussis population over time and a reduction in genetic diversity. These changes might have resulted from the introduction of pertussis vaccines in Denmark and other parts of Europe. The predominant strains currently circulating in Denmark resemble those in other European countries.

PMID:
22515990
PMCID:
PMC3358084
DOI:
10.3201/eid1805.110812
[Indexed for MEDLINE]
Free PMC Article

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