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Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):43-7. doi: 10.1016/j.plefa.2012.03.008. Epub 2012 Apr 18.

Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids.

Author information

1
Program in Integrative Nutrition and Complex Diseases and the Center for Environmental and Rural Health, Texas A&M University, College Station, TX 77843, USA.

Abstract

Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and multifaceted, resulting in an incomplete understanding of their molecular mechanisms of action. Here, we focus on a highly conserved mechanism of n-3 PUFA, which is the alteration of the organization of the plasma membrane. We highlight recent work demonstrating that enrichment of n-3 PUFA in the plasma membrane alters the lateral organization of membrane signaling assemblies (i.e. lipid rafts). This mechanism is central for n-3 PUFA regulation of downstream signaling, T-cell activation, transcriptional activation, and cytokine secretion. We conclude that these studies provide strong evidence for a predominant mechanism by which n-3 PUFA function in colon cancer prevention.

PMID:
22515942
PMCID:
PMC3404206
DOI:
10.1016/j.plefa.2012.03.008
[Indexed for MEDLINE]
Free PMC Article

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