Format

Send to

Choose Destination
Helicobacter. 2012 Jun;17(3):163-75. doi: 10.1111/j.1523-5378.2011.00931.x. Epub 2012 Mar 20.

The association between Barrett's esophagus and Helicobacter pylori infection: a meta-analysis.

Author information

1
Department of Epidemiology, University of NorthTexas Health Science Center, 3500 Camp Bowie Boulevard Fort Worth, TX 76107, USA. lori.fischbach@unthsc.edu

Abstract

OBJECTIVE:

The effect of Helicobacter pylori on Barrett's esophagus is poorly understood. We conducted a meta-analysis to summarize the existing literature examining the effect that H. pylori has on Barrett's esophagus.

DESIGN:

 We performed a comprehensive search to identify studies pertaining to the association between H. pylori and Barrett's esophagus. We conducted meta-regression analyses to identify sources of variation in the effect of H. pylori on Barrett's esophagus.

RESULTS:

 Our analysis included a total of 49 studies that examined the effect of H. pylori on Barrett's esophagus and seven studies that examined the effect of cag A positivity on Barrett's esophagus. Overall, H. pylori, and even more so cag A, tended to be protective for Barrett's esophagus in most studies; however, there was obvious heterogeneity across studies. The effect of H. pylori on Barrett's esophagus varied by geographic location and in the presence of selection and information biases. Only four studies were found without obvious selection and information bias, and these showed a protective effect of H. pylori on Barrett's esophagus (Relative risk = 0.46 [95% CI: 0.35, 0.60]).

CONCLUSIONS:

 Estimates for the effect of H. pylori on Barrett's esophagus were heterogeneous across studies. We identified selection and information bias as potential sources of this heterogeneity. Few studies without obvious selection and information bias have been conducted to examine the effect of H. pylori on Barrett's esophagus, but in these, H. pylori infection is associated with a reduced risk of Barrett's esophagus.

PMID:
22515353
PMCID:
PMC3335759
DOI:
10.1111/j.1523-5378.2011.00931.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center