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Nat Rev Mol Cell Biol. 2012 Apr 18;13(5):328-35. doi: 10.1038/nrm3335.

Intercellular communication: diverse structures for exchange of genetic information.

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1
Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernández Almagro, 3, 28029 Madrid, Spain.

Abstract

An emerging concept is that cellular communication in mammals can be mediated by the exchange of genetic information, mainly in the form of microRNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are taken up by an acceptor cell. Transfer of genetic material can also occur through intimate membrane contacts between donor and acceptor cells. Specialized cell-cell contacts, such as synapses, have the potential to combine these modes of genetic transfer.

PMID:
22510790
PMCID:
PMC3738855
DOI:
10.1038/nrm3335
[Indexed for MEDLINE]
Free PMC Article
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