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Nat Rev Genet. 2012 Apr 18;13(5):329-42. doi: 10.1038/nrg3174.

A beginner's guide to eukaryotic genome annotation.

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Department of Human Genetics, Eccles Institute of Human Genetics, School of Medicine, University of Utah, Salt Lake City, Utah 84112-5330, USA.


The falling cost of genome sequencing is having a marked impact on the research community with respect to which genomes are sequenced and how and where they are annotated. Genome annotation projects have generally become small-scale affairs that are often carried out by an individual laboratory. Although annotating a eukaryotic genome assembly is now within the reach of non-experts, it remains a challenging task. Here we provide an overview of the genome annotation process and the available tools and describe some best-practice approaches.

[Indexed for MEDLINE]

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