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Chimerism. 2011 Oct-Dec;2(4):111-3. doi: 10.4161/chim.2.4.19053.

Layers of regulation in induction of mixed chimerism by anti-CD40L.

Author information

1
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

The pathways regulating immunological tolerance are complex and overlapping. Here, we comment on our findings that the PD-1, CTLA-4, LAG-3 and TGFβ inhibitory molecules are all involved in mediating peripheral CD8 T‑cell tolerance induced by anti-CD40L and allogeneic bone marrow transplantation in mice. These observations suggest the possibility of targeted manipulation of these pathways for induction of mixed hematopoietic chimerism for donor-specific transplantation tolerance.

KEYWORDS:

CD8 T cells; anti-CD40L; bone marrow transplantation; mixed chimerism; tolerance

PMID:
22509427
PMCID:
PMC3321881
DOI:
10.4161/chim.2.4.19053
[Indexed for MEDLINE]
Free PMC Article

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