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PLoS One. 2012;7(4):e34665. doi: 10.1371/journal.pone.0034665. Epub 2012 Apr 11.

Roles of the Drosophila SK channel (dSK) in courtship memory.

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1
Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America.

Abstract

A role for SK channels in synaptic plasticity has been very well-characterized. However, in the absence of simple genetic animal models, their role in behavioral memory remains elusive. Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship memory assay to investigate the contribution of this channel to memory. Using two independent dSK alleles, a null mutation and a dominant negative subunit, we show that while dSK negatively regulates the acquisition of short-term memory 30 min after a short training session, it is required for normal long-term memory 24 h after extended training. These findings highlight important functions for dSK in courtship memory and suggest that SK channels can mediate multiple forms of behavioral plasticity.

PMID:
22509342
PMCID:
PMC3324495
DOI:
10.1371/journal.pone.0034665
[Indexed for MEDLINE]
Free PMC Article
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