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Database (Oxford). 2012 Apr 15;2012:bas019. doi: 10.1093/database/bas019. Print 2012.

The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012.

Author information

1
Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK. teresa.k.attwood@manchester.ac.uk

Abstract

The PRINTS database, now in its 21st year, houses a collection of diagnostic protein family 'fingerprints'. Fingerprints are groups of conserved motifs, evident in multiple sequence alignments, whose unique inter-relationships provide distinctive signatures for particular protein families and structural/functional domains. As such, they may be used to assign uncharacterized sequences to known families, and hence to infer tentative functional, structural and/or evolutionary relationships. The February 2012 release (version 42.0) includes 2156 fingerprints, encoding 12 444 individual motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. Here, we report the current status of the database, and introduce a number of recent developments that help both to render a variety of our annotation and analysis tools easier to use and to make them more widely available. Database URL: www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/.

PMID:
22508994
PMCID:
PMC3326521
DOI:
10.1093/database/bas019
[Indexed for MEDLINE]
Free PMC Article

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