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Arch Surg. 2012 Apr;147(4):366-72. doi: 10.1001/archsurg.2012.35.

Prognostic significance of tumor-infiltrating lymphocytes for patients with colorectal cancer.

Author information

1
Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 160 Ilsimri, Hwasun-eup, Hwasun-gun, Jeonnam 519-809, Korea.

Abstract

OBJECTIVE:

To evaluate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in patients with colorectal cancer.

DESIGN:

A retrospective review of prospectively collected data.

SETTING:

Tertiary care hospital.

PATIENTS:

A total of 546 patients who underwent curative surgery for primary nonmetastatic colorectal cancers from May 1, 2004, through December 31, 2007.

MAIN OUTCOME MEASURES:

The prognostic value of macroscopic ulceration, tumor border configuration, and TILs at the invasive margin was assessed.

RESULTS:

The low TIL group was significantly correlated with a poorly differentiated status and perineural invasion. During the median 54-month follow-up period, the low TIL group had significantly lower 5-year overall survival and disease-free survival rates than the high TIL group of patients with stage III colorectal cancer (P = .005 and P = .03, respectively); however, for patients with stage I and II cancers, the survival rates did not differ between the 2 groups. The 5-year overall survival and 5-year disease-free survival rates were significantly different between the high and low TIL groups of patients with rectal cancer (P = .003 and P = .01, respectively). The multivariate analysis confirmed that the TIL grade was significantly and independently associated with a worse prognosis for overall survival but not for disease-free survival.

CONCLUSIONS:

An inflammatory cell reaction at the tumor invasive border is considered a useful predictor of survival after colorectal cancer surgery, particularly for patients with stage III disease or rectal cancer.

PMID:
22508783
DOI:
10.1001/archsurg.2012.35
[Indexed for MEDLINE]

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