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Genes Dev. 2012 Apr 15;26(8):751-5. doi: 10.1101/gad.191163.112.

A complex Polycomb issue: the two faces of EZH2 in cancer.

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  • 1Cancer Center, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. hock.hanno@mgh.harvard.edu

Abstract

In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651-656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.

PMID:
22508723
PMCID:
PMC3337450
DOI:
10.1101/gad.191163.112
[PubMed - indexed for MEDLINE]
Free PMC Article
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