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J Clin Endocrinol Metab. 2012 Jul;97(7):2475-81. doi: 10.1210/jc.2011-3248. Epub 2012 Apr 16.

Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men.

Author information

1
Diabetes and Metabolic Medicine, Postgraduate Medical School, University of Surrey, Daphne Jackson Road, Manor Park, Guildford GU2 7WG, United Kingdom.

Abstract

CONTEXT:

High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol in women. This may be due to gender differences in very-low-density lipoprotein 1 (VLDL(1))- and VLDL(2)-TG and fatty acid kinetics.

OBJECTIVE:

Our objective was to investigate whether there are differences in VLDL(1)- and VLDL(2)-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease.

RESEARCH DESIGN AND METHODS:

Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL(1)-TG and VLDL(2)-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging.

PARTICIPANTS:

Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG.

RESULTS:

The women had lower visceral fat and higher sc fat than the men (P < 0.001 and P < 0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P < 0.03). VLDL(2)-TG PR corrected for fat-free mass was higher in the women (P < 0.001). VLDL(2)-TG and VLDL(2)-cholesterol pools were higher in the women (P < 0.001 and P < 0.008). VLDL(1)-TG FCR and PR and VLDL(2)-TG FCR were not different between genders.

CONCLUSION:

Fatty acid and VLDL(2)-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels.

PMID:
22508714
DOI:
10.1210/jc.2011-3248
[Indexed for MEDLINE]

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