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Aust N Z J Psychiatry. 2012 Apr;46(4):374-83. doi: 10.1177/0004867411432073. Epub 2012 Jan 5.

The impact of depression heterogeneity on inhibitory control.

Author information

1
Discipline of Psychiatry, Sydney Medical School, University of Sydney, Australia.

Abstract

OBJECTIVE:

Major depressive disorder (MDD) is associated with deficits in executive cognitive function, including inhibitory control. However, inconsistencies have been found across studies. Depression is a heterogeneous disorder and these inconsistencies may therefore relate to heterogeneity in relatively small samples.

METHOD:

Here we sought to examine event-related potentials (ERPs) during a cognitive Go/No-Go task in melancholic (n = 60) and non-melancholic depressed patients (n = 54) relative to controls (n = 114).

RESULTS:

Behavioural responses indicate that inhibitory control processes are differentially affected by subtypes of depression such that melancholic patients exhibit a greater number of commission errors and more variable response rates in comparison to non-melancholic patients and controls respectively. However, ERPs do not differ during a cognitive Go/No-Go task when ERPs associated with correct responses are examined.

CONCLUSIONS:

These findings indicate that while patients with melancholia differ from patients without melancholia and controls, no neurophysiological differences are observed when controlling for observable behavioural impairment.

PMID:
22508597
DOI:
10.1177/0004867411432073
[Indexed for MEDLINE]

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