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Toxicol In Vitro. 2012 Aug;26(5):727-31. doi: 10.1016/j.tiv.2012.03.013. Epub 2012 Apr 5.

Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S.

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European Commission, Joint Research Centre, Institute for Health and Consumer Protection, EURL ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing), Via E. Fermi 2749, I-21027 Ispra (VA), Italy.


In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation.

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