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Can J Physiol Pharmacol. 2012 May;90(5):509-14. doi: 10.1139/y2012-060. Epub 2012 Apr 17.

Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy.

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Department of Exercise and Nutrition Sciences, University at Buffalo, NY 14214, USA.


Reducing intestinal cholesterol absorption with plant sterol consumption is a well-characterized strategy to lower LDL-C and potentially reduce cardiovascular disease risk. However, over 50 years of clinical research demonstrate that there is significant heterogeneity in the individual LDL-C lowering response to plant sterol therapy. A clear understanding of why plant sterols work effectively in some individuals but not in others will ensure optimal integration of plant sterols in future personalized nutritional lipid-lowering strategies. This review will examine the current knowledge base surrounding the metabolic and genetic determinants of LDL-C lowering in response to plant sterol consumption.

[Indexed for MEDLINE]

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