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J Matern Fetal Neonatal Med. 2012 Nov;25(11):2470-4. doi: 10.3109/14767058.2012.684165. Epub 2012 May 17.

Male gender promotes an increased inflammatory response to lipopolysaccharide in umbilical vein blood.

Author information

1
Department of Obstetrics and Gynaecology, London, Ontario, Canada.

Abstract

OBJECTIVES:

To establish gender-specific differences in maternal and fetal immune response in healthy human fetuses at term.

METHODS:

Forty-five women with elective caesarean sections for uncomplicated singleton pregnancies were recruited for two studies. Using a multiplex biomarker immunoassay system, unstimulated maternal and fetal plasma concentrations of interleukin (IL)-1β, IL-1ra, IL-6, IL-8, macrophage inflammatory protein (MIP)-1α, and tumor necrosis factor (TNF)-α were measured from one study population. Lipopolysaccharide (LPS)-stimulated cytokine response was measured in a second study.

RESULTS:

There were no significant gender differences in either maternal or fetal unstimulated plasma cytokine concentrations, but concentrations of the proinflammatory cytokines IL-1β and IL-6 were significantly greater in male fetal LPS-stimulated samples than in female fetal samples.

CONCLUSIONS:

Blood of male fetuses mounts a larger pro-inflammatory response to lipopolysaccharide (LPS). This heightened response could be a critical pathway in promoting premature rupture of membranes (PPROM) and may be associated with life long differential gender response to infection.

PMID:
22506729
DOI:
10.3109/14767058.2012.684165
[Indexed for MEDLINE]

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