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Semin Cell Dev Biol. 2012 Sep;23(7):722-8. doi: 10.1016/j.semcdb.2012.03.017. Epub 2012 Apr 3.

Glutathione synthesis and its role in redox signaling.

Author information

1
University of Southern California, Los Angeles, CA 90089, United States.

Abstract

Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells. It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and glutathione synthetase, and its level is well regulated in response to redox change. Accumulating evidence suggests that GSH may play important roles in cell signaling. This review will focus on the biosynthesis of GSH, the reaction of S-glutathionylation (the conjugation of GSH with thiol residue on proteins), GSNO, and their roles in redox signaling.

PMID:
22504020
PMCID:
PMC3422610
DOI:
10.1016/j.semcdb.2012.03.017
[Indexed for MEDLINE]
Free PMC Article

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