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Clin Neurophysiol. 2012 Oct;123(10):1917-24. doi: 10.1016/j.clinph.2012.01.027. Epub 2012 Apr 12.

Multimodality language mapping in patients with left-hemispheric language dominance on Wada test.

Author information

1
Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA.

Abstract

OBJECTIVE:

We determined the utility of electrocorticography (ECoG) and stimulation for detecting language-related sites in patients with left-hemispheric language-dominance on Wada test.

METHODS:

We studied 13 epileptic patients who underwent language mapping using event-related gamma-oscillations on ECoG and stimulation via subdural electrodes. Sites showing significant gamma-augmentation during an auditory-naming task were defined as language-related ECoG sites. Sites at which stimulation resulted in auditory perceptual changes, failure to verbalize a correct answer, or sensorimotor symptoms involving the mouth were defined as language-related stimulation sites. We determined how frequently these methods revealed language-related sites in the superior-temporal, inferior-frontal, dorsolateral-premotor, and inferior-Rolandic regions.

RESULTS:

Language-related sites in the superior-temporal and inferior-frontal gyri were detected by ECoG more frequently than stimulation (p < 0.05), while those in the dorsolateral-premotor and inferior-Rolandic regions were detected by both methods equally. Stimulation of language-related ECoG sites, compared to the others, more frequently elicited language symptoms (p < 0.00001). One patient developed dysphasia requiring in-patient speech therapy following resection of the dorsolateral-premotor and inferior-Rolandic regions containing language-related ECoG sites not otherwise detected by stimulation.

CONCLUSIONS:

Language-related gamma-oscillations may serve as an alternative biomarker of underlying language function in patients with left-hemispheric language-dominance.

SIGNIFICANCE:

Measurement of language-related gamma-oscillations is warranted in presurgical evaluation of epileptic patients.

Comment in

PMID:
22503906
PMCID:
PMC3658143
DOI:
10.1016/j.clinph.2012.01.027
[Indexed for MEDLINE]
Free PMC Article

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