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Trends Pharmacol Sci. 2012 May;33(5):268-72. doi: 10.1016/j.tips.2012.03.007. Epub 2012 Apr 13.

Structure-based drug screening for G-protein-coupled receptors.

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1
Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.

Abstract

G-protein-coupled receptors (GPCRs) represent a large family of signaling proteins that includes many therapeutic targets; however, progress in identifying new small molecule drugs has been disappointing. The past 4 years have seen remarkable progress in the structural biology of GPCRs, raising the possibility of applying structure-based approaches to GPCR drug discovery efforts. Of the various structure-based approaches that have been applied to soluble protein targets, such as proteases and kinases, in silico docking is among the most ready applicable to GPCRs. Early studies suggest that GPCR binding pockets are well suited to docking, and docking screens have identified potent and novel compounds for these targets. This review will focus on the current state of in silico docking for GPCRs.

PMID:
22503476
PMCID:
PMC3523194
DOI:
10.1016/j.tips.2012.03.007
[Indexed for MEDLINE]
Free PMC Article
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