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Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.

mTOR signaling in growth control and disease.

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1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.

PMID:
22500797
PMCID:
PMC3331679
DOI:
10.1016/j.cell.2012.03.017
[Indexed for MEDLINE]
Free PMC Article
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