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Zhong Yao Cai. 2011 Dec;34(12):1912-5.

[Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice].

[Article in Chinese]

Author information

1
College of Pharmacy, Jilin Medical College, Jilin 132013, China. rainbowguanjiao@sina.com

Abstract

OBJECTIVE:

To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice.

METHODS:

Schisandrin in mice plasma and tissues including heart, liver, spleen, lung and kidney was quantitatively determined by HPLC.

RESULTS:

The concentration-time curve of Schisandra chinensis extract was described by a single compartment model, Cmax was (2.17 +/- 0.27) mg/ mL, t(max) was (1.00 +/- 0.32) h, AUC0-->infinity, was (4.07 +/- 0.62) mg x h/mL. The sequence of distribution of schisandrin in mice body was as follows: liver > plasma > kidney > lung > heart > spleen.

CONCLUSION:

The distribution of extract in the body is abroad. Liver has relative high concentration of schisandrin, which is beneficial to the treatment of hepatic disease.

PMID:
22500430
[Indexed for MEDLINE]

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