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F1000 Med Rep. 2012;4:8. doi: 10.3410/M4-8. Epub 2012 Apr 2.

Telomeres in disease.

Abstract

Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clinical diseases. We also discuss the potential role of telomere elongation as a therapy in diseases, and more controversially, the prevention/reversal of aging.

PMID:
22500192
PMCID:
PMC3318193
DOI:
10.3410/M4-8
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