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Blood. 2012 Apr 12;119(15):3376-7. doi: 10.1182/blood-2012-02-406751.

ALDH marks leukemia stem cell.

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1
Oregon Health & Science University, USA.

Abstract

In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreover, persistence of this population after therapy is a marker of clinically significant minimal residual disease.

PMID:
22500050
DOI:
10.1182/blood-2012-02-406751
[Indexed for MEDLINE]
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