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Nat Rev Neurosci. 2012 Apr 13;13(5):308-24. doi: 10.1038/nrn3210.

Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.

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1
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

Erratum in

  • Nat Rev Neurosci. 2012 Aug;13(8):597.

Abstract

mRNAs can be targeted to specific neuronal subcellular domains, which enables rapid changes in the local proteome through local translation. This mRNA-based mechanism links extrinsic signals to spatially restricted cellular responses and can mediate stimulus-driven adaptive responses such as dendritic plasticity. Local mRNA translation also occurs in growing axons where it can mediate directional responses to guidance signals. Recent profiling studies have revealed that both growing and mature axons possess surprisingly complex and dynamic transcriptomes, thereby suggesting that axonal mRNA localization is highly regulated and has a role in a broad range of processes, a view that is increasingly being supported by new experimental evidence. Here, we review current knowledge on the roles and regulatory mechanisms of axonal mRNA translation and discuss emerging links to axon guidance, survival, regeneration and neurological disorders.

PMID:
22498899
PMCID:
PMC3682205
DOI:
10.1038/nrn3210
[Indexed for MEDLINE]
Free PMC Article
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