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Trends Cardiovasc Med. 2011 Jan;21(1):20-7. doi: 10.1016/j.tcm.2012.01.004.

Resistin and cardiovascular disease.

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1
Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA 94350, USA.

Abstract

Resistin has been implicated in coronary atherosclerotic disease and congestive heart failure. Recent studies have extended its involvement in peripheral artery disease. Despite some controversial data, the mainstream clinical literature supports that resistin is associated with both coronary and peripheral artery diseases including ischemic stroke. In this review, the multiple roles of resistin as screening, diagnostic, and prognostic marker for cardiovascular disease are discussed. The independence of resistin in disease prediction and diagnosis appears complicated by its confounders, such as C-reactive protein. A clear-cut biomarker function of resistin in cardiovascular disease needs be clarified by additional large-scale, well-designed prospective studies.

PMID:
22498016
DOI:
10.1016/j.tcm.2012.01.004
[Indexed for MEDLINE]
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