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Am J Perinatol. 2012 Aug;29(7):551-6. doi: 10.1055/s-0032-1310527. Epub 2012 Apr 11.

Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis.

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1
Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec, Canada.

Erratum in

  • Am J Perinatol. 2014 Jun;31(6):e3. von Dadelzen, Peter [corrected to von Dadelszen, Peter].

Abstract

OBJECTIVE:

To determine whether early administration of aspirin prevents severe and mild preeclampsia.

STUDY DESIGN:

A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated.

RESULTS:

Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia.

CONCLUSION:

Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia.

PMID:
22495898
DOI:
10.1055/s-0032-1310527
[Indexed for MEDLINE]
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