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Trends Microbiol. 2012 May;20(5):243-50. doi: 10.1016/j.tim.2012.03.004. Epub 2012 Apr 9.

Staphylococcus aureus determinants for nasal colonization.

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Interfaculty Institute of Microbiology and Infection Medicine, University Hospital Tübingen, University of Tübingen, Elfriede-Aulhorn Straße 6, 72076 Tübingen, Germany.


Approximately 20% of the healthy human population is persistently colonized in the nasal cavity with Staphylococcus aureus, which constitutes a major risk for infection. S. aureus seems to predominantly colonize the anterior part of the nasal cavity by adhering to nasal surface structures and escaping the host innate and adaptive immune responses. Several bacterial and host factors that play a role in these processes have been identified in the past few years and were in part functionally evaluated in appropriate colonization models. However, the dynamics of host-pathogen crosstalk is only partially understood.

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