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Int J Mol Epidemiol Genet. 2012;3(1):48-55. Epub 2012 Feb 28.

Patients with Panton-Valentine leukocidin positive Staphylococcus aureus infections run an increased risk of longer hospitalisation.

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1Children Clinical University Hospital, Riga, Latvia.


Staphylococcus aureus is a major cause of purulent infections. The spectrum of staphylococcal infections varies from mild superficial to invasive life-threatening diseases due to S. aureus ability to produce a wide range of virulence factors, including toxins. A prospective observational study was conducted in the Children Clinical University Hospital in Riga, Latvia. During a period of sixteen months from November 2006 to March 2008 224 S. aureus isolates were collected. Our study revealed that Panton-Valentine leukocidine (PVL) genes are carried by a high number (75%) of S. aureus isolates recovered from children hospitalised in the Children Clinical University hospital. Most of these isolates were associated with abscesses and other skin and soft tissue infections. Patients with PVL positive invasive infections stayed significantly longer in hospital than patients with PVL negative invasive infections. Clonal distribution of PVL positive S. aureus isolates were closely related, which provides evidence for the wide spread of PVL producing spa type t435 and ST121 staphylococci in community.


BURP; MLST; Panton-Valentine leukocidin; S. aureus spa typing; ST121; Staphylococcus aureus; methicillin resistance; t435


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