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Anticancer Res. 2012 Apr;32(4):1339-46.

The value of induction chemotherapy for survival in patients with non-small cell lung cancer treated with radiotherapy.

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1
Department of Oncology, Uppsala University, Uppsala, Sweden.

Abstract

AIM:

The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC).

PATIENTS AND METHODS:

Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (≥50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts.

RESULTS:

Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75).

CONCLUSION:

We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination.

PMID:
22493368
[Indexed for MEDLINE]

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