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Am J Clin Nutr. 2012 May;95(5):1089-95. doi: 10.3945/ajcn.111.031088. Epub 2012 Apr 4.

Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk.

Author information

1
Department of Medicina Interna e Specialistica, Laboratorio di Nutrizione Clinica, Facoltà di Medicina, University of Palermo, Palermo, Italy. silbus@tin.it

Abstract

BACKGROUND:

Oxidative and inflammatory stresses are involved in the pathogenesis of atherosclerosis. The consumption of fruit and vegetables is associated with improved health and reduced cardiovascular risk. Red oranges have a high content of antioxidant and antiinflammatory substances, but there is a paucity of data concerning their effects on cardiovascular biomarkers in subjects with increased cardiovascular risk.

OBJECTIVE:

We investigated the effect of red orange juice intake on endothelial function, oxidative stress, and markers of inflammation in subjects with increased cardiovascular risk.

DESIGN:

Nineteen nondiabetic subjects with increased cardiovascular risk (aged 27-56 y) were included in a randomized, placebo-controlled, single-blind crossover study and compared with 12 healthy, nonobese control subjects. In 2 periods of 7 d each with a 3-d interval, each participant alternatively received 500 mL red orange juice/d and 500 mL placebo/d in a random sequence. All measurements were performed in the morning after overnight fasting.

RESULTS:

Endothelial function, which was measured as flow-mediated dilation, significantly improved and was normalized (5.7% compared with 7.9%; P < 0.005) after 1 wk of red orange juice consumption. Similarly, concentrations of high-sensitivity C-reactive protein, IL-6, and TNF-α significantly decreased (P < 0.001). Red orange juice had no significant effect on nitric oxide plasma concentrations.

CONCLUSION:

A 7-d consumption of red orange juice ameliorates endothelial function and reduces inflammation in nondiabetic subjects with increased cardiovascular risk. This trial was registered at biomedcentral.com as ISRCTN39987296.

PMID:
22492368
DOI:
10.3945/ajcn.111.031088
[Indexed for MEDLINE]

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