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Clin Infect Dis. 2012 May;54(9):1230-9. doi: 10.1093/cid/cis199.

Preeminence of Staphylococcus aureus in infective endocarditis: a 1-year population-based survey.

Collaborators (265)

Hoen B, Duval X, Alla F, Bouvet A, Briançon S, Cambau E, Celard M, Chirouze C, Danchin N, Doco-Lecompte T, Delahaye F, Etienne J, Iung B, Le Moing V, Obadia J, Leport C, Poyart C, Revest M, Selton-Suty C, Strady C, Tattevin P, Vandenesch F, Bernard Y, Chocron S, Chirouze C, Hoen B, Plesiat P, Abouliatim I, De Place C, Tattevin P, Revest M, Donnio P, Alla F, Carteaux J, Doco-Lecompte T, Lion C, Aissa N, Selton-Suty C, Baehrel B, Jaussaud R, Nazeyrollas P, Strady C, Vernet V, Cambau E, Duval X, Iung B, Nataf P, Chidiac C, Celard M, Delahaye F, Obadia J, Vandenesch F, Aumaître H, Frappier J, Le Moing V, Oziol E, Sotto A, Sportouch C, Poyart C, Bouvet A, Vandenesch F, Celard M, Bes M, Abassade P, Abrial E, Acar C, Aissa N, Alexandra J, Amireche N, Amrein D, Andre P, Appriou M, Arnould M, Assayag P, Atoui A, Aziza F, Baille N, Bajolle N, Battistella P, Baumard S, Ben Ali A, Bertrand J, Bialek S, Bois Grosse M, Boixados M, Borlot F, Bouchachi A, Bouche O, Bouchemal S, Bourdon J, Bouvet A, Brasme L, Bricaire F, Brochet E, Bruntz J, Cady A, Cailhol J, Caplan M, Carette B, Carteaux J, Cartry O, Cazorla C, Celard M, Chamagne H, Champagne H, Chanques G, Chastre J, Chevalier B, Chirouze C, Chometon F, Christophe C, Cohen A, Colin de Verdiere N, Danchin N, Daneluzzi V, David L, De Lentdecker P, Delahaye F, Delcey V, Deleuze P, Donal E, Duval X, Deroure B, Descotes-Genon V, Didier Petit K, Dinh A, Doat V, Duchene F, Duhoux F, Dupont M, Ederhy S, Epaulard O, Evest M, Faucher J, Fantin B, Fauveau E, Ferry T, Fillod M, Floch T, Fraisse T, Frapier J, Freysz L, Fumery B, Gachot B, Gallien S, Gandjbach I, Garcon P, Gaubert A, Genoud J, Ghiglione S, Godreuil C, Grentzinger A, Groben L, Gherissi D, Guéret P, Hagege A, Hammoudi N, Heliot F, Henry P, Herson S, Hoen B, Houriez P, Hustache-Mathieu L, Huttin O, Imbert S, Iung B, Jaureguiberry S, Kaaki M, Konate A, Kuhn J, Kural Menasche S, Lafitte A, Lafon B, Lanternier F, Le Chenault V, Le Moing V, Lechiche C, Lefèvre-Thibaut S, Lefort A, Leguerrier A, Lemoine J, Lepage L, Leport C, Lepousé C, Leroy J, Lesprit P, Letranchant L, Loisance D, Loncar G, Lorentz C, Mabo P, Magnin-Poull I, May T, Makinson A, Man H, Mansouri M, Marçon O, Maroni J, Masse V, Maurier F, Meyohas M, Michel P, Michelet C, Mechaï F, Merceron O, Messika-Zeitoun D, Metref Z, Meyssonnier V, Mezher C, Micheli S, Monsigny M, Mouly S, Mourvillier B, Nallet O, Nataf P, Nazeyrollas P, Noel V, Obadia J, Oziol E, Papo T, Payet B, Pelletier A, Perez P, Petit J, Philippart F, Piet E, Plainvert C, Popovic B, Porte J, Pradier P, Ramadan R, Revest M, Richemond J, Rodermann M, Roncato M, Roigt I, Ruyer O, Saada M, Schwartz J, Selton-Suty C, Simon M, Simorre B, Skalli S, Spatz F, Strady C, Sudrial J, Tartiere L, Terrier De La Chaise A, Thiercelin M, Thomas D, Thomas M, Toko L, Tournoux F, Tristan A, Trouillet J, Tual L, Vahanian A, Verdier F, Vernet Garnier V, Vidal V, Weyne P, Wolff M, Wynckel A, Zannad N, Zinzius P.

Author information

1
Cardiologie, Centre Hospitalier Universitaire, Nancy, France.

Abstract

BACKGROUND:

Observational studies showed that the profile of infective endocarditis (IE) significantly changed over the past decades. However, most studies involved referral centers. We conducted a population-based study to control for this referral bias. The objective was to update the description of characteristics of IE in France and to compare the profile of community-acquired versus healthcare-associated IE.

METHODS:

A prospective population-based observational study conducted in all medical facilities from 7 French regions (32% of French individuals aged ≥18 years) identified 497 adults with Duke-Li-definite IE who were first admitted to the hospital in 2008. Main measures included age-standardized and sex-standardized incidence of IE and multivariate Cox regression analysis for risk factors of in-hospital death.

RESULTS:

The age-standardized and sex-standardized annual incidence of IE was 33.8 (95% confidence interval [CI], 30.8-36.9) cases per million inhabitants. The incidence was highest in men aged 75-79 years. A majority of patients had no previously known heart disease. Staphylococci were the most common causal agents, accounting for 36.2% of cases (Staphylococcus aureus, 26.6%; coagulase-negative staphylococci, 9.7%). Healthcare-associated IE represented 26.7% of all cases and exhibited a clinical pattern significantly different from that of community-acquired IE. S. aureus as the causal agent of IE was the most important factor associated with in-hospital death in community-acquired IE (hazard ratio [HR], 2.82 [95% CI, 1.72-4.61]) and the single factor in healthcare-associated IE (HR, 2.54 [95% CI, 1.33-4.85]).

CONCLUSIONS:

S. aureus became both the leading cause and the most important prognostic factor of IE, and healthcare-associated IE appeared as a major subgroup of the disease.

PMID:
22492317
DOI:
10.1093/cid/cis199
[Indexed for MEDLINE]

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