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J Biomater Appl. 2013 Aug;28(2):219-31. doi: 10.1177/0885328212443393. Epub 2012 Apr 5.

Enhanced visualization of biodegradable polymeric vascular scaffolds by incorporation of gold, silver and magnetite nanoparticles.

Author information

1
Institute for Biomedical Engineering, University of Rostock, Rostock, Germany. frank.luderer@uni-rostock.de

Abstract

Due to improved tissue regeneration and the enabling of post-operative minimally invasive interventions in the same vessel segment, biodegradable polymeric scaffolds represent a competitive approach to permanent metallic stents in vascular applications. Despite these advantages some challenges, such as the improvement of the scaffold mechanics and enhancement of scaffold visibility during the implantation procedure, are persisting. Therefore, the scope of our studies was to investigate the potential of gold, silver and magnetite nanoparticles incorporated in a polymeric blend of poly(L-lactide)/poly(4-hydroxybutyrate) for image enhancement in X-ray, magnetic resonance or near-infrared imaging. Their impact on mechanical properties of such modified scaffold materials was also evaluated.

KEYWORDS:

Nanoparticles; X-ray imaging; magnetic resonance imaging; near-infrared imaging; polymeric scaffolds

PMID:
22492201
DOI:
10.1177/0885328212443393
[Indexed for MEDLINE]
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