Paraquat-induced convulsion and death: a report of five cases

Toxicol Ind Health. 2013 Sep;29(8):722-7. doi: 10.1177/0748233712442712. Epub 2012 Apr 4.

Abstract

Paraquat (PQ) is a potent toxicant for humans, and poisoning with PQ is associated with high mortality. Patients with severe PQ-induced poisoning may die of multiple organ failure involving the circulatory and respiratory systems. Death resulting from epilepsy-like convulsions, which are infrequently noted reported with PQ poisoning, is observed clinically with this condition. This study presents the clinical data of five patients with severe PQ-induced poisoning who died of epilepsy-like convulsions, and related publications were reviewed in order to investigate the pathogenesis, clinical manifestations, and prognosis of these convulsions. Our results may help prevent this event and improve the success of treatment.

Keywords: Paraquat; complications; convulsive; poisoning; seizure.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood-Brain Barrier*
  • Fatal Outcome
  • Female
  • Humans
  • Paraquat / pharmacokinetics
  • Paraquat / poisoning*
  • Seizures / chemically induced
  • Seizures / pathology*
  • Tomography Scanners, X-Ray Computed
  • Young Adult

Substances

  • Paraquat