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Clin Infect Dis. 2012 Jun;54(12):1774-7. doi: 10.1093/cid/cis290. Epub 2012 Apr 5.

Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis.

Author information

1
Federal University of Bahia, University Hospital Prof. Edgard Santos, Salvador-Bahia, Brazil. smistro@ufba.br

Abstract

This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48 [99% CI, .36-.64]); n = 1233), respectively.

PMID:
22491505
DOI:
10.1093/cid/cis290
[Indexed for MEDLINE]

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