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Nat Rev Microbiol. 2012 Apr 11;10(5):317-22. doi: 10.1038/nrmicro2764.

A new player in the puzzle of filovirus entry.

Author information

1
Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, Virginia 22908-20732, USA. jw7g@virginia.edu

Abstract

Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.

PMID:
22491356
PMCID:
PMC3540776
DOI:
10.1038/nrmicro2764
[Indexed for MEDLINE]
Free PMC Article

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